Applying a COVID-19 Sample-pooling Technique to Forensics Identification of Illicit Drugs

Authors

  • Ori Gutman Division of Identification and forensic sciences, Israel https://orcid.org/0000-0001-7697-5590
  • Yiffat Katz The National Drugs Analysis Laboratory, Israel Police, DIFS, Jerusalem, Israel
  • Haim Dayan The National Drugs Analysis Laboratory, Israel Police, DIFS, Jerusalem, Israel
  • Simcha Shimron The National Drugs Analysis Laboratory, Israel Police, DIFS, Jerusalem, Israel
  • Reut Isaschar The National Drugs Analysis Laboratory, Israel Police, DIFS, Jerusalem, Israel
  • Emuna Raviv The National Drugs Analysis Laboratory, Israel Police, DIFS, Jerusalem, Israel
  • Dana Sonenfeld The National Drugs Analysis Laboratory, Israel Police, DIFS, Jerusalem, Israel

DOI:

https://doi.org/10.21467/ijm.1.1.4932

Abstract

This paper presents a method for materially speeding up the identification process of suspect illicit drugs by pooling samples that require GC-MS analysis. This method can be applied to samples seized from a single suspect that are similar in appearance and therefore meet the Israeli Dangerous Drug Ordinance requirements for sampling. A complementary test (GC, TLC, or FTIR) conducted separately on each of the sampled units can prove conclusively that all units contain the same drug. This study shows that even with large differences in relative weight of mixes in a pool, each drug is easily identifiable by GC-MS and dominant peaks do not overshadow minority substances. By using this method, a narcotics lab can improve its throughput of expert opinions in narcotics cases, and at the same time save resources, extend instrument life, and be more environment-friendly.

Keywords:

Pooling, GCMS, Identification, Illicit drug analysis

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References

Dangerous Drugs Ordinance (2021), 5733-1973. Ministry of health – State of Israel, 64. https://www.health.gov.il/LegislationLibrary/Samim_01_EN.pdf

Garg, J., Singh, V., Pandey, P., Verma, A., Sen, M., Das, A., & Agarwal, J. (2021). Evaluation of sample pooling for diagnosis of COVID‐19 by real time‐PCR: A resource‐saving combat strategy. Journal of medical virology, 93(3), 1526-1531.

Ghosh, S., Rajwade, A., Krishna, S., Gopalkrishnan, N., Schaus, T. E., Chakravarthy, A., & Gopalkrishnan, M. (2020). Tapestry: A single-round smart pooling technique for COVID-19 testing. MedRxiv.‏

Hans, K. M. C., Müller, S., & Sigrist, M. W. (2012). Infrared attenuated total reflection (IR‐ATR) spectroscopy for detecting drugs in human saliva. Drug testing and analysis, 4(6), 420-429.‏

Kempfert, K. (1988). Forensic drug analysis by GC/FT-IR. Applied spectroscopy, 42(5), 845-849.‏

Kranenburg, R. F., Verduin, J., Stuyver, L. I., de Ridder, R., van Beek, A., Colmsee, E., & Van Asten, A. C. (2020). Benefits of derivatization in GC–MS-based identification of new psychoactive substances. Forensic Chemistry, 20, 100273.‏

Mitrevski, B., Wynne, P., & Marriott, P. J. (2011). Comprehensive two-dimensional gas chromatography applied to illicit drug analysis. Analytical and bioanalytical chemistry, 401(8), 2361-2371.‏‏

Petkova, E., Antman, E. M., & Troxel, A. B. (2020). Pooling data from individual clinical trials in the COVID-19 era. Jama, 324(6), 543-545.‏

Quinn, T. C., Brookmeyer, R., Kline, R., Shepherd, M., Paranjape, R., Mehendale, S., & Bollinger, R. (2000). Feasibility of pooling sera for HIV-1 viral RNA to diagnose acute primary HIV-1 infection and estimate HIV incidence. Aids, 14(17), 2751-2757.‏

Rajananda, V., Nair, N. K., & Navaratnam, V. (1985). An evaluation of TLC systems for opiate analysis. Bull Narc, 37(1), 35-47.‏

SCIENTIFIC WORKING GROUP FOR THE ANALYSIS OF SEIZED DRUGS (SWGDRUG) RECOMMENDATIONS. Version 8_FINAL_ForPosting_092919.pdf. https://www.swgdrug.org/Documents/SWGDRUG%20Recommendations%20Version%208_FINAL_ForPosting_092919.pdf

Shani-Narkiss, H., Gilday, O. D., Yayon, N., & Landau, I. D. (2020). Efficient and practical sample pooling for high-throughput PCR diagnosis of COVID-19. MedRxiv.‏

Wacharapluesadee, S., Kaewpom, T., Ampoot, W., Ghai, S., Khamhang, W., Worachotsueptrakun, K., ... & Hemachudha, T. (2020). Evaluating the efficiency of specimen pooling for PCR‐based detection of COVID‐19. Journal of medical virology, 92(10), 2193-2199.‏

Yuksel, B., & Sen, N. (2018). Development and validation of a GC-FID method for determination of cocaine in illicit drug samples. Journal of research in pharmacy, 22(4).

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Published

2022-05-17

How to Cite

[1]
O. Gutman, “Applying a COVID-19 Sample-pooling Technique to Forensics Identification of Illicit Drugs”, Int. J. Methodol., vol. 1, no. 1, pp. 26–43, May 2022.