A Systematic Review of Garlic and Ginger as Medicinal Spices against Viral Infections


  • Cosmos Ifeanyi Onyiba Michael Okpara University of Agriculture, Umudike, Abia state




Garlic (Allium sativum) and Ginger (Zingiber officinale) are globally utilized herbal medicinal spices. This systematic review discussed available evidence on the direct and indirect antiviral activities of garlic and ginger. Studies investigating the antiviral activities of garlic and ginger were searched and retrieved from four databases, including Google Scholar, PubMed, Science direct, and MEDLINE. Data search and retrieval were done up to 15 October 2021. A total of 28 studies were included in this systematic review (garlic = 18 studies; ginger = 10 studies). Fresh garlic aqueous extract and fresh ginger hot water extract were the most investigated forms of garlic and ginger, respectively. There was minimal evidence on the prophylactic antiviral effect of garlic and ginger, moderate evidence on the therapeutic and prophylactic/therapeutic antiviral effects, and minimal evidence on the enhancement of the immune system against viral infections. The low-moderate quality evidence on the direct and indirect antiviral effects of garlic and ginger has provided the necessary background to instigate further high-quality investigations to validate the current information, address the grey areas, and provide valuable insights into the possible utility of garlic and ginger as raw materials in drug development against viral infections.


Garlic and Ginger, Antiviral activity, Viral Infections


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Payne S. Family Coronaviridae. Viruses 2017; 149–158

Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern Lancet 2020; 395(10223):470-473.

Cucinotta D, Vanelli M. WHO Declares COVID-19 a Pandemic. Acta Biomed. 2020; 91(1):157-160.

Barnes PM, Bloom B, Nahin RL. Complementary and alternative medicine use among adults and children: United States, 2007. Health Stat. Report. 2008; 10, 1–23.

Jaber MA, Al-Mossawi. A Susceptibility of some multiple resistant bacteria to garlic extracts. Afr J Biotechnol. 2007; 6(6): 771-776.

Kao SH, Hsu CH, Su SN, Hor WT, Chang WH, et al., Identification and immunologic characterization of an allergen, alliin-lyase, from garlic (Allium sativum). J Allergy Clin Immunol 2004; 113(1): 161-168.

Posadzki P, Watson LK, Alotaibi A, Ernst E. Prevalence of herbal medicine use by UK patients/ consumers: a systematic review of surveys. Clin. Med. Lond. (Lond) 2013; 13, 126–131

Amarakoon S, Jayasekara D. A review on garlic (Allium sativum L.) as a functional food. Journal of Pharmacognosy and Phytochemistry 2017; 6. 1777-1780.

Eja ME, Asikong BE, Abriba C, Arikpo GE, Anwan EE, Enyi-Idoh KH. A comparative assessment of the antimicrobial effects of garlic (Allium sativum) and antibiotics on diarrheagenic organisms. Southeast Asian J Trop Med Public Health 2007; 38(2): 343-348.

Lemar KM, Aon MA, Cortassa S, O'Rourke B, Müller CT, Lloyd D. Diallyl disulphide depletes glutathione in Candida albicans: oxidative stress-mediated cell death studied by two-photon microscopy. Yeast 2007; 24(8): 695-706.

Islam M, Kusumoto Y, Al-Mamun MA. Cytotoxicity and cancer (HeLa) cell killing efficacy of aqueous garlic (Allium sativum) extract. J Sci Res. 2011; 3(2): 375-382.

Shih PC, Kuo CH, Juang JY, Liu CH, Hsu L, Liu CT. Effects of garlic oil on the migration of neutrophil-like cell studied by using a chemotactic gradient Labchip. Bio Med Res Int. 2010; ID: 319059, 9 pages

Banerjee S, Maulik M, Manchanda S, Dinda A, Das T, Maulik S. Garlic-induced alteration in rat liver and kidney morphology and associated changes in endogenous antioxidant status. Food Chem Toxicol. 2001; 39(8): 793-797.

Bhargava S, Dhabhai K, Batra A, Sharma A, Malhotra B. Zingiber Officinale: Chemical And Phytochemical Screening And Evaluation Of Its Antimicrobial Activities. Journal of Chemical and Pharmaceutical Research 2012; 4(1):360-364

Demin G, Yingying Z. Comparative antibacterial activities of crude polysaccharides and flavonoids from Zingiber officinale and their extraction. Am. J. Trop. Med. 2010; 5: 235-238.

Dhanik J, Arya N, Nand V. Review on Zingiber officinale. Journal of Pharmacognosy and Phytochemistry 2017; 6(3): 174-184.

Grzanna R, Lindmark L, Frondoza CG. Ginger – An herbal Medical Product with Broad Anti- Inflammatory Action. J. Med. Food 2005; 8:125-132.

Langner E, Greifenberg S, Gruenwald J. Ginger: History and Use. Adv Ther. 1998; 15(1):25-44.

Kabuto H, Nishizawa M, Tada M, Higashio C, Shishibori T, Kohno M. Zingerone [4-(4-hydroxy-3-methoxyphenyl)-2-butanone] prevents 6-hydroxydopamine-induced dopamine depression in mouse striatum and increases superoxide scavenging activity in serum. Neurochem. Res. 2005; 30:325-232.

Uz E, Karatas OF, Mete E, Bayrak R, Bayrak O, Atmaca AF et al., The effect of dietary ginger (Zingiber officinals Rosc.) on renal ischemia/reperfusion injury in rat kidneys. Ren Fail 2009; 31(4):251-260.

Garace S, Sankari M, Gopi. Antimicrobial Activity of Ethanolic Extract of Zingiber Officinale – An in vitro Study. U. Santo Grace et al /J. Pharm. Sci. & Res. 2017; 9(9), 1417-1419

Nasri H, Nematbakhsh M, Ghobadi S, Ansari R, Shahinfard N, et al., Preventive and curative effects of ginger extract against histopathologic changes of gentamicin-induced tubular toxicity in rats. Int J Prev Med; 2013 4(3): 316-321.

Shukla Y, Singh M. Cancer preventive properties of ginger: a brief review. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association 2007; 45(5), 683–690.

Fesseha H, Goa E. Therapeutic value of garlic (Allium sativum): A Review. Adv Food Technol Nutr Sci Open J. 2019; 5(3): 107-117.

Sharma, Neha. Efficacy of Garlic and Onion against virus. International Journal of Research in Pharmaceutical Sciences 2019; 10, 3578-3586.

Najim, A. Potential health benefits and scientific review of ginger. Journal of Pharmacognosy and Phytotherapy 2017; 9. 111-116.

Walder R, Kalvatchev Z, Garzaro D, Barrios M, Apitz-Castro R. In vitro suppression of HIV-1 replication by ajoene [(e)-(z)-4,5,9-trithiadodeca-1,6,11-triene-9 oxide]. Biomed Pharmacother. 1997; 51 (9):397-403.

Liu ZF, Fang F, Dong YS, Li G, Zhen H. Experimental study on the prevention and treatment of murine cytomegalovirus hepatitis by using allitridin. Antiviral Res. 2004; 61 (2):125-8

Fang F, Li H, Cui W, Dong Y. Treatment of hepatitis caused by cytomegalovirus with allitridin injection--an experimental study. J Tongji Med Univ. 1999; 19(4):271-4.

Li YN, Huang F, Liu XL, Shu SN, Huang YJ, Cheng HJ, Fang F. 2013. Allium sativum-derived allitridin inhibits Treg amplification in cytomegalovirus infection. J Med Virol. Mar; 85(3):493-500.

Zhang J, Wang H, Xiang ZD, Shu SN, Fang F. Allitridin inhibits human cytomegalovirus replication in vitro. Mol Med Rep. 2013; 7(4):1343-9.

Vijgen L., Keyaerts E, van-Damme E, Peumans W, Clercq E, Balzarini J et al., Inhibition of SARS coronavirus in vitro by plant compounds of the Alliaceae family. International Conference on SARS - one year after the (first) outbreak. Lübeck, 08.-11.05.2004. Düsseldorf, Köln: German Medical Science; Doc04sarsP9.03. http://www.egms.de/en/meetings/sars2004/04sars125.shtml

Chavan RD, Shinde P, Girkar K, Madage R, Chowdhary A. Assessment of Anti-Influenza activity and hemagglutination inhibition of Plumbago indica and Allium sativum extracts. Phcog Res. 2016; 8:105-11.

Mehrbod P, Amini E, Kheiri M. Antiviral activity of garlic extract on Influenza virus. Iranian J Virol. 2009; 3, 19-23.

Tsai Y, Cole LL, Davis LE, Lockwood SJ, Simmons V, Wild GC. Antiviral Properties of Garlic: In vitro Effects on Influenza B, Herpes Simplex and Coxsackie Viruses. Planta Med. 1985; 51(5):460-1.

Yi X, Feng F, Xiang Z, Ge L. The effects of allitridin on the expression of transcription factors T-bet and GATA-3 in mice infected by murine cytomegalovirus. J Med Food 2005; 8(3):332-6.

Doostmohammadian F, Shomali T, Mosleh N, Mohammadi M. In Ovo evaluation of antiviral effects of aqueous garlic (Allium sativum) extract against a velogenic strain of Newcastle disease virus. J Herbmed Pharmacol. 2020; 9 (3):232-238.

Aboubakr HA, Nauertz A, Luong NT, Agrawal S, El-Sohaimy SA, Youssef MM et al., In Vitro Antiviral Activity of Clove and Ginger Aqueous Extracts against Feline Calicivirus, a Surrogate for Human Norovirus. J Food Prot. 2016; 79 (6):1001-12.

Shojai MT, Ghalyanchi LA, Karimi V, Barin A, Sadri N. The effect of Allium sativum (Garlic) extract on infectious bronchitis virus in specific pathogen free embryonic egg. Avicenna J Phytomed. 2016; 6(4):458-267.

Xie YC, Ying G, Yongzheng H, Ying ZB. Allicin and Glycyrrhizic Acid Display Antiviral Activity against Latent and Lytic Kaposi Sarcoma-associated Herpesvirus. Infectious Microbes & Diseases 2020; 2. 30-34.

Rasool A, Khan MU, Ali MA, Anjum AA, Ahmed I, Aslam A et al., Anti-avian influenza virus H9N2 activity of aqueous extracts of Zingiber officinalis (Ginger) and Allium sativum (Garlic) in chick embryos. Pak J Pharm Sci. 2017; 30 (4):1341-1344.

Harazem R, Rahman SA, Kenawy A. Evaluation of Antiviral Activity of Allium Cepa and Allium Sativum Extracts Against Newcastle Disease Virus. alexandria journal of veterinary sciences 2019; 61, 108-118.

Arify T, Jaisree S, Manimaran K, Valavan S, Sundaresan A. Antiviral Effects of Garlic (Allium sativum) and Nilavembu (Andrographis paniculata) against Velogenic Strain of Newcastle Disease Virus- An In-ovo Study. International Journal of Livestock Research 2018; 8(10), 157-164.

Chang JS, Wang KC, Yeh CF, Shieh DE, Chiang LC. Fresh ginger (Zingiber officinale) has antiviral activity against human respiratory syncytial virus in human respiratory tract cell lines. J. Ethnopharmacol. 2013; 145(1):146-51.

Subbaiah GV, Reddy KS, JayavardhanaRao Y, Shanmugam B, Ravi S, Shanmugam KR et al., 6-Gingerol prevents free transition metal ion [Fe (II)]-induced free radical-mediated alterations by In vitro and Ndv growth in chicken eggs by In ovo. Phcog Mag 2018; 14:S167-74.

Kaushik S, Jangra G, Kundu V, Yadav JP, Kaushik S. Antiviral activity of Zingiber officinale (Ginger) ingredients against the Chikungunya virus Virus disease 2020; 1-7.

Koch C, Reichling J, Schneele J, Schnitzler P. Inhibitory effect of essential oils against herpes simplex virus type 2. Phytomedicine. 2008; 15(1-2):71-78.

Camero M, Lanave G, Catella C, Capozza P, Gentile A, Fracchiolla G et al., Virucidal activity of ginger essential oil against caprine alphaherpesvirus-1. Vet Microbiol. 2019; 230:150-155.

Denyer CV, Jackson P, Loakes DM, Ellis MR, Young DA. Isolation of antirhinoviral sesquiterpenes from ginger (Zingiber officinale). J Nat Prod. 1994; 57(5):658-62.

Schnitzler P, Koch C, Reichling J. Susceptibility of drug-resistant clinical herpes simplex virus type 1 strains to essential oils of ginger, thyme, hyssop, and sandalwood. Antimicrob Agents Chemother. 2007; 51(5):1859-62.

Imanishi N, Andoh T, Mantani N, Sakai S, Terasawa K, Shimada Y et al., Macrophage-mediated inhibitory effect of Zingiber officinale Rosc, a traditional oriental herbal medicine, on the growth of influenza A/Aichi/2/68 virus. Am J Chin Med. 2006; 34 (1):157-69.

Dimitrov, D. Virus entry: molecular mechanisms and biomedical applications. Nat Rev Microbiol. 2004; 2. 109–122

Lee, K. J., Novella, I. S., Teng, M. N., Oldstone, M. B., and de La Torre, J. C. NP and L proteins of lymphocytic choriomeningitis virus (LCMV) are sufficient for efficient transcription and replication of LCMV genomic RNA analogs. J. Virol. 2000; 74, 3470–3477.

Hass, M., Gölnitz, U., Müller, S., Becker-Ziaja, B., and Günther, S. Replicon system for Lassa virus. J. Virol. 2004; 78, 13793–13803.

Hoenen, T., Kolesnikova, L., and Becker, S. Recent advances in filovirus- and arenavirus-like particles. Future Virol. 2007; 2, 193–203.

Ziegler, C. M., Eisenhauer, P., Bruce, E. A., Weir, M. E., King, B. R., Klaus, J. P., et al., The lymphocytic choriomeningitis virus matrix protein PPXY late domain drives the production of defective interfering particles. PLoS Pathog. 2016; 12:e1005501.

Janssen H, Reesink HW, Lawitz EJ, Zeuzem S, Rodriguez-Torres M, Patel K, van der Meer AJ, Patick AK, Chen A, Zhou Y, Persson R, King BD, Kauppinen S, Levin AA, Hodges MR. Treatment of HCV Infection by Targeting MicroRNA. New England J Medicine 2013, 368: 1685–1694.

Lazzarin A, Clotet B, Cooper D, Reynes J, Arasteh K, Nelson M, Katlama C, Stellbrink H-J, Delfraissy J-F, Lange J, Huson L, DeMasi R, Wat C, Delehanty J, Drobnes C, Salgo M. Efficacy of enfuvirtide in patients infected with drug-resistant HIV-1 in Europe and Australia. New England J Medicine 2003, 348: 2186–2185.

Fatkenheuer G, Poznia AL, Johnson MA, et al., Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV. Nature medicine 2005, 11: 1170–1172.

Lin K, Gallay P. Curing a viral infection by targeting the host: the example of cyclophilin inhibitors. Antiviral research 2013, 99: 68–77.

Mohan S, Elhassan Taha MM, Makeen HA, Alhazmi HA, Al Bratty M, Sultana S, Ahsan W, Najmi A, Khalid A. Bioactive Natural Antivirals: An Updated Review of the Available Plants and Isolated Molecules. Molecules. 2020 Oct 22;25(21):4878.

Chaachouay N, Douira A, Zidane L. COVID-19, prevention and treatment with herbal medicine in the herbal markets of Salé Prefecture, North-Western Morocco. Eur J Integr Med. 2021; 42:101285

Hong-Zhi, D. U., Hou, X. Y., Miao, Y. H., Huang, B. S., Liu, D. H. Traditional Chinese Medicine: an effective treatment for 2019 novel coronavirus pneumonia (NCP). Chin. J. Nat. Med. 2020; 18 (3), 226–230.

Lu, H. Drug treatment options for the 2019-new coronavirus (COVID-19). Biosci. Trends 2020; 14 (1), 69–71. doi: 10.5582/bst.2020.01020

Xu, K., Cai, H., Shen, Y., Ni, Q., Chen, Y., Hu, S., et al., Management of Corona Virus disease-19 (COVID-19): The Zhejiang Experience. J. Zhejiang Univ. Med. Sci. 2020; 49 (1), 0.

Aoki-Utsubo C, Chen M, Hotta H. Virucidal and Neutralizing Activity Tests for Antiviral Substances and Antibodies. Bio-protocol 2018; 8(10): e2855.

Alcami A, Ghazal P, Yewdell JW. Viruses in control of the immune system. Workshop on molecular mechanisms of immune modulation: lessons from viruses. EMBO reports 2002; 3(10), 927–932.

Domingo-Calap P. Viral evolution and Immune responses. J Clin Microbiol Biochem Technol. 2019; 5(2): 013-018.

Rojas JM, Avia M, Martín V, Sevilla N. IL-10: A Multifunctional Cytokine in Viral Infections. J Immunol Res. 2017; 6104054.

Kikkert M. Innate Immune Evasion by Human Respiratory RNA Viruses. J Innate Immun. 2020; 12(1):4-20.

Arreola R, Quintero-Fabián S, López-Roa RI, Flores-Gutiérrez EO, Reyes-Grajeda JP, Carrera-Quintanar L et al., Immunomodulation and anti-inflammatory effects of garlic compounds. Journal of immunology research 2015: 401630.

Eikai K, Naoto U, Shigeo K, Yoichi I. Immunomodulatory Effects of Aged Garlic Extract, The Journal of Nutrition 2001; 1075S–1079S

Elmowalid GA, Abd El-Hamid MI, Abd El-Wahab AM, Atta M, Abd El-Naser G, Attia AM. Garlic and ginger extracts modulated broiler chicks innate immune responses and enhanced multidrug resistant Escherichia coli O78 clearance. Comparative immunology, microbiology and infectious diseases 2019; 66, 101334.

Reem OA, Kamel N, El-Shinnawy A. Immunomodulatory effect of garlic oil extract on Schistosoma mansoni infected mice, Asian Pacific Journal of Tropical Medicine 2015; 999-1005.

Schäfer G, Kaschula CH. The immunomodulation and anti-inflammatory effects of garlic organosulfur compounds in cancer chemoprevention. Anti-cancer agents in medicinal chemistry 2014; 14(2), 233–240.

Kanhere A, Hertweck A, Bhatia U. et al., T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements. Nat Commun. 2012; 3, 1268.

Amri M, Touil-Boukoffa C. In vitro anti-hydatic and immunomodulatory effects of ginger and [6]-gingerol. Asian Pacific Journal of Tropical Medicine 2016; (8):749-756.

Carrasco FR, Schmidt G, Romero AL, et al., Immunomodulatory activity of Zingiber officinale Roscoe, Salvia officinalis L. and Syzygium aromaticum L. essential oils: evidence for humor- and cell-mediated responses. J Pharm Pharmacol. 2009; 61 (7):961-967.

Mahboubi M. Zingiber officinale Rosc. Essential oil, a review on its composition and bioactivity. Clin Phytosci. 2019; 5, 6.

Zhou HL, Deng YM, Xie QM. The modulatory effects of the volatile oil of ginger on the cellular immune response in vitro and in vivo in mice. J Ethnopharmacol. 2006; 105 (1-2):301–5.






Review Article

How to Cite

C. I. Onyiba, “A Systematic Review of Garlic and Ginger as Medicinal Spices against Viral Infections”, Extsv. Rev., vol. 2, no. 1, pp. 32–44, Mar. 2022.