Effectiveness of Coconut (Cocos nucifera) Extracts as an Inhibitor Against Aspergillosis





The study of the Effectiveness of Coconut (Cocos nucifera) Extract Against Aspergilosis revealed that, the testing of some brown coconut extracts, coconut water, positive control and negative control on Aspergillus sp fungi showed clear zone formed around the agar well, ethanolic extract showed 26.00 mm, 25.33 mm and 20.00 mm, for Aspergillus fumigatus, Aspergillus flavus and Aspergillus brasiliensis respectively, donystatin antifungal drug was 22.67 mm, 17.67 mm and 20.83 mm for Aspergillus brasiliensis, Aspergillus fumigatus and Aspergillus flavus respectively, methanolic, aqueous, coconut water and distilled water showed no zone of inhibition. The ethanolic extract of brown coconut inhibited the growth/expansion of Aspergillus sp. The best inhibitor was acquired from the administration of ethanolic extract with an average diameter of 26.00 mm diameter of the inhibition zone. The nutritional and health implication of coconut fruit consumption should be encouraged because of its’ potency which can form the basis to exploit Cocos nucifera for therapeutic benefits. 


Donystatin, Aspergillosis, Brown coconut


Download data is not yet available.


D. Denning , C. H. Pashley, D. Hartl, A. Wardlaw, C. Godet, S. D. Giacco, L. Delhaes and S. Sergejeva, "Fungal allergy in Asthma-state of the art and research needs," Clinical and Translational Allergy, vol. 4, no. 1, 2014.

A. Warris, A. Bercusson and D. Armstrong-James, "Aspergillus colonization and antifungal immunity in cystic fibrosis patients," Medical mycology, vol. 57, pp. 118-126, 2019.

J. Chen, Q. Yang, J. Huang and L. Li, "Risk Factors for Invasive Pulmonary Aspergillosis and Hospital Mortality in Acute-On-Chronic Liver Failure Patients: A Retrospective-Cohort study," International Journal of Medical Sciences, vol. 10, no. 12, pp. 1625-1631, 2013.

N. L. Smith and D. W. Denning, "Underlying conditions in chronic pulmonary aspergillosis including simple aspergilloma.," The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology, vol. 37.

A. Goel, "Pulmonary Aspergillosis," Mediconotebook, 2015.

J. Guinea, M. Torres-Narbona, P. Gijon and P. Munoz, "Pulmonary aspergillosis in patients with chronic obstructive pulmonary disease: incidence, risk factors, and outcome," Clinical Microbiology and Infection, vol. 16, no. 7, 2009.

C. Garcia-Vidal, A. Upton, K. A. Kirby and K. A. Marr, "Epidemiology of Invasive Mold Infections in Allogeneic Stem Cell Transplant Recipients: Biological Risk Factors for Infection According to Time after Transplantation," Clinical Infectious Diseases, vol. 47, no. 8, pp. 1041-50, 2008.

H.-S. Nam, K. Jeon, S.-W. Um, G. Y. Suh, M. Chung, H. Kim, O. J. Kwon and W.-J. Koh, "Clinical characteristics and treatment outcomes of chronic necrotizing pulmonary aspergillosis: a review of 43 cases," International journal of infectious diseases, vol. 14, no. 6, 2009.

F. Bongomin, S. Gago, R. O. Oladele and D. W. Denning, "Global and Multi-National Prevalence of Fungal Diseases-Estimate Precision," Journal of Fungi., vol. 3, no. 4, p. 57, 2017.

F. Bongomin, C. R. Batac, M. Richardson and D. Denning, "A Review of Onychomycosis Due to Aspergillus Species," Mycopathologia, vol. 183, no. 3, p. 485–493, 2018.

J. Durack, H. A. Boushey and S. V. Lynch, "Airway Microbiota and the Implications of Dysbiosis in Asthma," Current Allergy and Asthma Reports, vol. 116, no. 8, p. 52, 2016.

P. Alexia, D. Manuel, D. Nafissatou and P. Jean-Piierre, “Coconut water uses, composition and properties,” A Review, Fruits, vol. 67, no. 2, pp. 87-107, 2012.

A. Khoddami, M. A. Wilkes and T. H. Roberts, "Techniques for Analysis of Plant Phenolic Compounds," Molecules, vol. 18, pp. 2328-2375, 2013.

P. Appaiah, L. Sunil, K. K. A. Gopala and K. G. Suresh, "Phytochemicals and Antioxidant Activity of Testa Extracts of Commercial Wet and Dry Coconuts and Cakes," International Research Journal of Pharmacy, vol. 7, no. 9, pp. 9-13, 2017.

C. P. Davis, "MedicineNet," MedicineNet, 5 May 2021. [Online]. Available: https://medicinenet.com/aspergillus_infection_aspergillosis/article.htm. [Accessed 10 December 2021].

M. A. Lopes and B. A. Larkins, "Endosperm origin, development and function," Plant Cell, vol. 5, pp. 1389-1399, 1993.

J. Janick and R. E. Paull, "The Encyclopedia of fruit & Nuts," CAB International: Wallingford, UK, p. 112, 2008.

J. W. Patrick and C. E. Offler, "Compartmentation of transport and transfer events in developing seeds," J. Exp. Bot, vol. 52, pp. 551-564, 2001.

U. S. D. o. A. (USDA), "National Nutrient Database for Standard Reference, Nuts, coconut water," 2008. [Online]. Available: : http://www.nal.usda.gov/fnic/foodcomp/cgi-bin/list_nut_edit.pl/. [Accessed December 2021].

E. Lima, C. Sousa, L. Meneses, N. Ximenes, S. J. Manuel, S. V. Germana, N. Lima, M. Patrocínio, D. Macedo and S. Vasconcelos, "Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review," Brazilian Journal of Medical and Biological Research, vol. 00, no. 00, pp. 1-12, 2015.






Graduate Research Articles

How to Cite

A. Olugbenga, N. G. Usman, and O. G. Barnabas, “Effectiveness of Coconut (Cocos nucifera) Extracts as an Inhibitor Against Aspergillosis”, Adv. J. Grad. Res., vol. 12, no. 1, pp. 48–54, May 2022.