Advanced Journal of Graduate Research 2024-05-16T11:34:11+00:00 Adv. J. Grad. Research Open Journal Systems <p align="justify"><a title="Click for Journal homepage" href="" target="_blank" rel="noopener"><img style="float: right; padding-left: 15px; padding-right: 5px;" src="" alt="AJGR" /></a>Advanced Journal of Graduate Research is a multidisciplinary, international journal featuring the work of graduate students and young researchers. This journal seeks to disseminate the work of emerging students who focus on scientific/technical content, regardless of their academic discipline. <em>Adv. J. Grad. Res.</em> publishes research carried out by graduate students and young researchers (Bachelor's degree students and Master's degree students) that sound scientifically and technically valid. This journal will serve as a global platform to broadcast new research initiatives being carried out by today's brightest youths as part of their graduate project.<br />Advanced Journal of Graduate Research is published by AIJR publisher (India) and registered with CrossRef with doi: 10.21467/ajgr and ISSN of this journal is 2456-7108 [online].</p> Comparative Analysis of Phytocompound Variations in Leaves, Bark and Roots of Allspice (Pimenta Dioica) Collections in Tanzania 2024-02-06T11:37:59+00:00 Raymond Malinda Lutege Pavithravani B Venkataramana Joseph Ndunguru <p>Allspice, scientifically known as Pimenta dioica, holds potential as a natural source of beneficial compounds that have been historically used to address various human health concerns. The aim of this research was to explore differences in the compounds found in parts of Allspice (i.e., the leaves, bark, and roots). Petroleum ether, dichloromethane, and methanol were used to extract the substances from each part; the resulting crude extracts were then analyzed using gas chromatography mass spectrometry. To interpret the obtained data, the National Institute of Standards and Technology database was referred to for a spectra analysis. The findings indicated that the leaves contained 81 phytocompounds, bark had 18 types, and roots exhibited 12 varieties. Prominent phytocompounds found in the leaves were eugenol in 72.24% – 73.91% of the total compounds detected. Bark was primarily composed of 1,4-Methanoazulene, decahydro-4,8,8-trimethyl-9-methylene-, [1S-(1. alpha.,3a. beta.,4. alpha.,8a. beta.)] in 74.35% – 84.24%; while roots contained γ-sitosterol at an 86.08% concentration level. In terms of solvent performance, methanol exhibited high efficiency on leaves, while dichloromethane demonstrated optimal results on bark and roots. The findings confirm significant variations in phytocompound composition in different parts of Allspice and underscores the importance of considering specific types of phytocompounds, as well as extraction techniques to achieve valuable outcomes.</p> 2024-02-06T00:00:00+00:00 Copyright (c) 2024 Raymond Malinda Lutege, Pavithravani B Venkataramana, Joseph Ndunguru Can Stem Cell Therapy be an Effective Therapeutic Option for Complex and Neurological Conditions? 2024-05-16T11:34:11+00:00 Sophea Lo Raymund Gantioque <p>This article explores the feasibility and potential benefits of stem cell therapy as a promising therapeutic intervention for individuals facing severe behavioral and cognitive impairments, targeting underlying neurological mechanisms to offer potential symptom improvement and function restoration, thereby enhancing the quality of life for patients and potentially alleviating stress and burnout among caregivers. The aims of the study include investigating the efficacy of stem cell therapy in addressing these impairments and evaluating its potential to alleviate caregiver burden. Through a comprehensive review of existing literature, clinical trials, and studies, this research synthesizes the mechanisms of stem cell therapy, potential applications, clinical trial outcomes, caregiver experiences, and economic implications. The methods employed involve analyzing diverse data sources to provide a holistic understanding of the possibilities and challenges associated with stem cell therapy. Key outcomes of the study include highlighting promising results from clinical trials targeting conditions such as autism spectrum disorder, Parkinson's disease, and Crohn's disease, which underscore the transformative potential of stem cell therapy in patient care. Additionally, economic implications suggest potential reductions in healthcare costs and alleviation of financial strain on individuals, families, and healthcare providers. Stem cell therapy represents a paradigm shift in healthcare, promising to redefine treatment approaches and alleviate broader societal burdens associated with complex neurological conditions. The relevance of the study lies in emphasizing the need for continued research, ethical considerations, and multidisciplinary collaboration to ensure the safe and effective integration of stem cell therapy into clinical practice, ultimately offering new hope and improved care for patients, caregivers, and healthcare systems worldwide.</p> 2024-05-16T00:00:00+00:00 Copyright (c) 2024 Sophea Lo, Raymund Gantioque