Synthesis, Degradation, Biocompatibility and Drug Release Studies of Bis 2-Hydroxy Ethyl Terephthalate-based Poly (Mannitol-Citric-Sebacate) Ester

Athira K Sunil; Sarkar K; Kaushik Chatterjee

doi:10.21467/jmm.1.1.9-16

Authors

Athira K Sunil Biomaterials and Tissue Engineering Laboratory Department of Materials Engineering Indian Institute of Science Bangalore
Sarkar K Biomaterials and Tissue Engineering Laboratory Department of Materials Engineering Indian Institute of Science Bangalore
Kaushik Chatterjee Biomaterials and Tissue Engineering Laboratory Department of Materials Engineering Indian Institute of Science Bangalore

DOI:

https://doi.org/10.21467/jmm.1.1.9-16

Abstract

Bis 2-Hydroxy Ethyl Terephthalate-based biodegradable poly(mannitol-citric-sebacate) has been synthesized by catalyst-free melt condensation process using two different diacids and Bis 2-Hydroxy Ethyl Terephthalate with D-mannitol as monomers having a potential to be metabolized in vivo. The biocompatibility of the polymer, Bis 2-Hydroxy Ethyl Terephthalate-poly(mannitol-citric-sebacate) has been tested using human primary stromal cells. In vitro degradation of Bis 2-Hydroxy Ethyl Terephthalate-poly(mannitol-citric-sebacate) polymer in Phosphate Buffered Saline solution carried out at physiological conditions indicates that the degradation goes to completion after 23 days. The usage of Bis 2-Hydroxy Ethyl Terephthalate-poly(mannitol-citric-sebacate) polymer as a drug carrier has been analyzed by doping the polymer with Doxorubicin model drug and the release rate has been studied by mass loss over time. The cumulative drug-release profiles exhibit a biphasic release with an initial burst release and cumulative 100 percent release within 14 days.

Keywords:

Bis 2-Hydroxy ethyl terephthalate (BHET), Biodegradable Polymer, Human Primary Stromal Cells, Biocompatibility, Scaffold, Drug-delivery

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Author Biographies

Athira K Sunil, Biomaterials and Tissue Engineering Laboratory Department of Materials Engineering Indian Institute of Science Bangalore

KVPY Fellow

Department of Materials Engineering

Sarkar K, Biomaterials and Tissue Engineering Laboratory Department of Materials Engineering Indian Institute of Science Bangalore

UGC Kothari Fellow

Department of Materials Engineering

Kaushik Chatterjee, Biomaterials and Tissue Engineering Laboratory Department of Materials Engineering Indian Institute of Science Bangalore

Assistant Professor

Department of Materials Engineering

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